Innexin Gap Junctions

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Partial rescue of an ogre mutant optic lobe phenotype.

Partial rescue of an ogre mutant optic lobe phenotype.

The image shows serial sections taken through the optic lobe of an ogre mutant. Glia express UAS-mCD8:GFP (green) and UAS-ogre under the transcriptional control of the nrv2GAL4 driver (Sun et al, 1999). The optic lobes of ogre flies expressing the UAS-ogre rescue construct in glia are always much larger than those observed in ogre animals (Optic lobe of ogre mutant adult) but they are still smaller than the optic lobes of wild types . Although all rescued animals have larger optic lobes than the mutant, rescue of the internal optic lobe structures is variable. This image shows an example of a poorly rescued optic lobe. Glia are highly disorganised compared to wild type morphology (which can be seen here). The best optic lobe rescue that we found can be seen here.

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