Innexin Gap Junctions

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Genetic interaction between Inx2TA181 and sodium pump mutants - leg phenotypes.


Genetic interaction between Inx2TA181 and sodium pump mutants - leg phenotypes.

Example of two legs taken from the same individual fly of genotype:
Inx2TA181/+ ; ATPαM116/+
Arrows indicate deformed joints (..and possibly segments also). Not all legs are as obviously deformed. Note that these are not complete fusions as seen when UAS-ogre is expressed in developing legs (Leg joint defects induced by UAS-ogre) but more closely resemble the phenotypes observed when UAS-inx2 is expressed in leg discs. Whether the underlying mechanism giving rise to aberrant leg development is the same, in the case of innexin overexpression and dominant innexin interaction with other loci, is open to debate. Flies were grown at 18C. All flies of this genotype failed to eclose.



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