Innexin Gap Junctions

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Inx2 and Ogre proteins co-localise in salivary gland cells.


Inx2 and Ogre proteins co-localise in salivary gland cells.

Innexin2 and myc-tagged Ogre colocalise in salivary gland cells. Shown above are two Z sections taken at different positions across the boundary of a pair of salivary gland cells. Inx2 (red, Alexa 555) and Ogre-myc (green, Alexa 488, myc-tagged Ogre) produce a yellow colour in the merged image at points where they overlap. Transgenically expressed Ogre-myc can accumulate within cells producing a weak green cytoplasmic background fluorescence. Size bar = 5μm. Inx2 and Inx3 are mutually dependent (Lehmann et al, 2006), so it is not surprising that endogenous Inx3 also co-localises with transgenic Ogre-myc in salivary gland cells. The potential interaction between Ogre and other innexins is not restricted to the salivary gland tissue: in brain neuropile glia, Inx2 colocalises with Ogre-myc.



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