Inx2 protein in embryonic epidermal cells near the end of dorsal closure.
A projection of Z-series images showing the distribution of Inx2 protein (B, blue) in epidermal cells of a 10-12 hour old, wild type embryo. The embryo has been antibody stained to detect fasciclinIII (A, red), an adhesion molecule located on cell plasma membranes. Arrowheads indicate where leading edge cells have joined at the dorsal surface midline of the embryo. Inx2 protein distribution is not obviously different in leading edge cells than in any other epidermal cells. This raises questions about whether studying innexins in a dorsal closure model of wound healing ( W. Wood et al. 2002, Wound healing recapitulates morphogenesis in Drosophila embryos.) would reveal any insights into the reported role of connexin-based gap junctions and wound healing ( C. Qiu et al. 2003, Targeting connexin43 expression accelerates the rate of wound repair.). C, merged image.