Innexin Gap Junctions

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Wing phenotypes observed expressing multiple UAS-innexins. UAS-ogre and UAS-inx2.


Wing phenotypes observed expressing multiple UAS-innexins. UAS-ogre and UAS-inx2.

Photograph of a wing from an animal of genotype UAS-ogre2UO15 / + ; C96GAL4 / UAS-inx23UE26. In this case the C96GAL4 ( Gustafson and Boulianne, 1996) line drives expression of both Ogre and Inx2 in the wing margin. Relatively weak wing serration is observed at the wing margin (arrowhead). The phenotype is generally only slightly more severe than when UAS-ogre2UO15 is expressed alone. UAS-inx23UE26 alone only produces very mild serration in a small fraction of offspring. Expressing pairs of different innexins in the wing margin (eg. UAS-ogre and UAS-inx2, as in this case) was attempted to try to uncover synergistic interactions between innexin subunits, that is, phenotypes that were much stronger, or even qualitatively different, than phenotypes observed when two identical innexins are expressed in the same pattern (eg. UAS-inx2 and UAS-inx2, two copies of inx2). Unfortunately, this synergy was never observed between UAS-ogre, UAS-inx2 and UAS-inx7 in studies of wing development.



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