Innexin Gap Junctions

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Inx2TA181 interaction with sodium pump alleles - example of weak Serrate-like phenotype.


Inx2TA181 interaction with sodium pump alleles - example of weak Serrate-like phenotype.

Photograph of a wing from a fly of genotype Inx2TA181/+; Df(2L)BSC7/+. The dominant Innexin2 allele Inx2TA181 genetically interacts with β subunits of the Na/K ATPase (sodium pump) producing a variety of phenotypes including altered bristle distribution at the leading edge of the wing (arrows). Mutant phenotypes are also observed in other tissues that express Inx2 during development, such as the eye. The deficiency line Df(2L)BSC removes a single copy of nrv1 and nrv2 sodium pump β subunits leaving a reduced number of wild type copies of these genes in the mutant fly. The deficiency Df(2L)BSC also removes a large number of other genes, but the genetic interaction between Inx2TA181 and sodium pump components was confirmed using single mutants of nrv2 and ATPα. Dominant Inx2 mutants were initially referred to as Stout alleles when they were first reported ( Florence and McGinnis 1998, A Genetic Screen of the Drosophila X Chromosome for Mutations That Modify Deformed Function).



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