Innexin Gap Junctions

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Inx2 and F-actin at the plasma membrane.

Inx2 and F-actin at the plasma membrane.

The image shows a section of plasma membrane from a pupal salivary gland that has been antibody-stained with rabbit anti-Inx2 polyclonal primary and a FITC conjugated secondary to detect Inx2 (green). F-actin (red) is detected using a phalloidin-rhodamine conjugate. Accumulations of F-actin (white arrows) are often found next to Inx2-containing gap junction plaques (yellow arrows). This may provide some structural rigidity to the membrane which may, or may not, be required for stable plaques to form. Whether this association between plaques and actin is important or is generalisable to other cell types is unknown. A short summary of innexin and actin positional-associations can be found here.

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