Innexin Gap Junctions


Drosophila innexins - inx6




Summary

inx6 is located at position 19C1 on the X chromosome near inx5 and fairly close to ShakB / inx8. Expressed sequence tags (ESTs) have not been reported for inx6 from any cDNA library but it does appear to be expressed. Using RNA probes, inx6 transcripts are detected in the developing wing discs and the cortex of the pupal central nervous system but are not detected in the embryo (Stebbings et al, 2002). inx7 transcript was not detected in all embryonic epithelia or in the CNS using the in situ RNA probe method but has been found in these locations using Inx7-specific antibodies (Ostrowski et al, 2008)....so, Inx6 (and Inx5) should not yet be dismissed from potentially having a role during embryogenesis. An Affymetrix array-based survey of gene expression (Chintapalli et al, 2007, GEO database, Innexin expression in the adult testes and ovary) indicates that, of all the tissues surveyed, inx6 transcript is most highly expressed in adult testes (although, it is not detected in the ovary, the corresponding female tissue). Relative to other members of the innexin gene family, the expression level of inx6 is always very low. Inx6 is similar to Inx5 in possessing an extremely long first extracellular loop (Inx6=97 amino acids, Inx5=115 amino acids, other innexins 61-63 amino acids) (Bauer et al, 2005). Another similarity shared by these two innexins is the predicted PDZ type I domain at their C-terminal end …the significance of which is currently unknown.



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Literature

(Publications prior to 2009 are based on data extracted from the textpresso text mining facility.)



Intercellular communication: the Drosophila innexin multiprotein family of gap junction proteins., Chem Biol., Bauer R, Loer B, Ostrowski K, Martini J, Weimbs A, Lechner H, Hoch M., 2005, 12(5):515-26 pubmed/NLM

Gap junctions in Drosophila: developmental expression of the entire innexin gene family., Mech Dev., Stebbings LA, Todman MG, Phillips R, Greer CE, Tam J, Phelan P, Jacobs K, Bacon JP, Davies JA., 2002, 113(2):197-205 pubmed/NLM

Innexins get into the gap., Bioessays, Phelan P, Starich TA., 2001, 23(5):388-96 pubmed/NLM


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