Innexin Gap Junctions


Drosophila innexins - inx5




Summary

inx5 is located on the X chromosome at position 18A4, relatively close to inx6 and ShakB / inx8. Expressed sequence tags (ESTs) corresponding to inx5 mRNA have been recovered from testis and head cDNA libraries (www.flybase.org). Microaaray analysis (Chintapalli et al, 2007) indicates that more inx5 is expressed in males than females (data from the gene expression omnibus- GEO, series GDS1526) probably due solely to the inx5 testis expression. inx5 transcripts are not detected in oocytes or the embryo but are fairly ubiquitous in larval wing discs and the cortex of the adult central nervous system. In both tissues the expression pattern of inx5 mRNA overlaps with the patterns of all other innexins, with the exception of the germline specific inx4 (Stebbings et al, 2002). Although most Drosophila innexins have first extracellular loops of 61-63 amino acids in length, inx5 has 115 amino acids in this loop. Its close neighbour, inx6, also has a long first extracellular loop of 98 amino acids (Bauer et al, 2005). The significance of the extra amino acids is unknown. Inx5 and Inx6 proteins are the only Drosophila innexins to possess predicted PDZ class I domains at the carboxy termini (Inx2 and Inx7 have predicted PDZ class II domains at these positions whereas the other innexins have no predicted PDZ domains).



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Literature

(Publications prior to 2009 are based on data extracted from the textpresso text mining facility.)



Intercellular communication: the Drosophila innexin multiprotein family of gap junction proteins., Chem Biol., Bauer R, Loer B, Ostrowski K, Martini J, Weimbs A, Lechner H, Hoch M., 2005, 12(5):515-26 pubmed/NLM

Gap junctions in Drosophila: developmental expression of the entire innexin gene family., Mech Dev., Stebbings LA, Todman MG, Phillips R, Greer CE, Tam J, Phelan P, Jacobs K, Bacon JP, Davies JA., 2002, 113(2):197-205 pubmed/NLM

Innexins get into the gap., Bioessays, Phelan P, Starich TA., 2001, 23(5):388-96 pubmed/NLM


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